Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 12/20 | 0.64 |
| ▸ | NOS3 | P29474 | 11/20 | 0.64 |
| ▸ | NOS1 | P29475 | 3/20 | 0.64 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214849 | 0.78 | NOS3 (1.00) | NOS2NOS3NOS1TAAR1 | |
| SCHEMBL8195096 | 0.78 | NOS2 (0.80) | NOS2NOS3NOS1TAAR1 | |
| SCHEMBL8218521 | 0.77 | NOS3 (0.70) | NOS2NOS3NOS1TAAR1 | |
| SCHEMBL8186392 | 0.76 | NOS2 (0.85) | NOS2NOS3NOS1TAAR1 | |
| SCHEMBL8208391 | 0.69 | NOS2 (0.59) | NOS2NOS3NOS1TAAR1 | |
| SCHEMBL10520069 | 0.65 | NPC1 (0.32) | — | |
| SCHEMBL11429097 | 0.62 | MEN1 (0.36) | TAAR1 | |
| SCHEMBL1264655 | 0.62 | NPC1 (0.48) | TAAR1 | |
| SCHEMBL8197502 | 0.61 | NOS2 (0.51) | NOS2NOS3NOS1 | |
| SCHEMBL7269732 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | claimed |
| WO-2000064904-A1 | 5,7-BICYCLIC AMIDINE DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-11-02 | — | — | WO | disclosed |