Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.56 |
| ▸ | EP300 | Q09472 | 8/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.53 |
| ▸ | POLL | Q9UGP5 | 3/20 | 0.49 |
| ▸ | PTGES | O14684 | 3/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 4/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | DLAT | P10515 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Clusianone SCHEMBL30120542 | 1.00 | SIRT1 (0.56) | SIRT1EP300HDAC11POLLPTGES | |
| SCHEMBL31171805 | 0.92 | SIRT1 (0.61) | SIRT1EP300HDAC11POLLPTGES | |
| Aristophenone A SCHEMBL31345818 | 0.88 | EP300 (0.69) | SIRT1EP300HDAC11POLLPTGES | |
| SCHEMBL8215247 | 0.88 | SIRT1 (0.68) | SIRT1EP300HDAC11POLLPTGES | |
| Hyperibone L SCHEMBL31345837 | 0.85 | SIRT1 (0.54) | SIRT1EP300HDAC11POLLPTGES | |
| Epiclusianone SCHEMBL29594618 | 0.83 | SIRT1 (0.52) | SIRT1EP300HDAC11POLLPTGES | |
| SCHEMBL16435085 | 0.81 | POLL (0.65) | SIRT1EP300HDAC11POLLPTGES | |
| Guttiferone O SCHEMBL31345820 | 0.81 | MET (0.61) | SIRT1EP300HDAC11POLLPTGES | |
| Guttiferone B SCHEMBL31345806 | 0.80 | MET (0.65) | SIRT1EP300HDAC11POLLPTGES | |
| SCHEMBL31345799 | 0.80 | EP300 (0.79) | SIRT1EP300HDAC11POLLPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000054760-A2 | BICYCLO (3.3.1) NONENES USEFUL FOR THE TREATMENT OF DIABETES AND HYPERTRIGLYCERIDEMIA | SHAMAN PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | claimed |
| WO-2000054760-A2 | BICYCLO (3.3.1) NONENES USEFUL FOR THE TREATMENT OF DIABETES AND HYPERTRIGLYCERIDEMIA | SHAMAN PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |