Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.84 |
| ▸ | MAPT | P10636 | 9/20 | 0.84 |
| ▸ | RAB9A | P51151 | 6/20 | 0.84 |
| ▸ | GAA | P10253 | 6/20 | 0.84 |
| ▸ | MEN1 | O00255 | 6/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.84 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.84 |
| ▸ | NPC1 | O15118 | 5/20 | 0.84 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | HPGD | P15428 | 8/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL656187 | 0.89 | MAPT (0.80) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL654015 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL5344833 | 0.88 | MAPT (0.78) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL16689457 | 0.88 | MAPT (0.78) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL610929 | 0.86 | ALDH1A1 (0.76) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL1693702 | 0.83 | MAPT (0.71) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL5898698 | 0.80 | IKBKB (0.71) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL6643722 | 0.80 | ALDH1A1 (0.60) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL17268776 | 0.80 | MAPT (0.80) | ALDH1A1MAPTRAB9AGAAMEN1 | |
| SCHEMBL5919452 | 0.77 | ALDH1A1 (0.63) | ALDH1A1MAPTRAB9AGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117645-A | SCREENING COMPOUND FOR SENSITIVITY TO A LUTENIZING HORMONE RELEASING HORMONE RECEPTOR PROTEIN; INCUBATING CELLS WITH TEST COMPOUND AND DETECTING BINDING | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-09-12 | — | — | US | disclosed |