Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191387 | 0.87 | TP53 (0.57) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL8184450 | 0.86 | KDM4E (0.49) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL8188664 | 0.84 | TP53 (0.43) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL8176463 | 0.83 | MAPT (0.43) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL8198899 | 0.83 | KDM4E (0.42) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL8199073 | 0.82 | ALDH1A1 (0.45) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL9215707 | 0.81 | DPP4 (0.34) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL22796688 | 0.81 | HSD17B10 (0.67) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL9213889 | 0.80 | GSK3B (0.36) | KDM4EHSD17B10SMN1; SMN2GAATSHR | |
| SCHEMBL9205154 | 0.76 | KDM5A (0.54) | KDM4EHSD17B10SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021447-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998033799-A1 | PYRROLOPYRAZOLOPYRIMIDINE COMPOUND AND MEDICINE COMPRISING THE SAME | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1998-08-06 | — | — | WO | disclosed |