Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14013827 | 0.88 | KDM5A (0.42) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL9215707 | 0.86 | DPP4 (0.34) | CDK2CCNA2CCNA1KDM5AKDM4C | |
| SCHEMBL11931245 | 0.81 | L3MBTL1 (0.49) | GSK3BKDM4EHSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL9205154 | 0.81 | KDM5A (0.54) | CDK2KDM5AKDM4CKDM4EHSD17B10 | |
| SCHEMBL8207281 | 0.80 | KDM4E (0.55) | KDM4EHSD17B10GAATSHRSMN1; SMN2 | |
| SCHEMBL8185805 | 0.77 | POLB (0.40) | KDM4EHSD17B10GAATSHRSMN1; SMN2 | |
| SCHEMBL14013828 | 0.77 | KDM4E (0.55) | KDM4EHSD17B10SMN1; SMN2MEN1MAPT | |
| SCHEMBL5826567 | 0.76 | MAPT (0.37) | KDM4EHSD17B10GAATSHRSMN1; SMN2 | |
| SCHEMBL11931282 | 0.76 | GSK3B (0.36) | GSK3BCDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL8191387 | 0.76 | TP53 (0.57) | KDM4EHSD17B10GAATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508549-B1 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO CO (JP) | 1995-04-26 | — | — | EP | disclosed |
| EP-0347252-B1 | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1993-05-05 | — | — | EP | disclosed |
| EP-0508549-A2 | New triazolopyrimidine and pyrazolopyrimidine derivatives useful for treating cachexia | SANKYO COMPANY LIMITED (JP) | 1992-10-14 | — | — | EP | disclosed |
| US-5086057-A | METHOD OF TREATING CACHEXIA AND CERTAIN NEW COMPOUNDS FOR USE IN THIS METHOD | SANKYO COMPANY LIMITED (JP) | 1992-02-04 | — | — | US | disclosed |
| US-5055479-A | For enhancing activity of lipoprotein lipase enzymes | SANKYO COMPANY, LIMITED (JP) | 1991-10-08 | — | — | US | disclosed |