Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 2/20 | 0.54 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623749 | 0.89 | KDM5A (0.45) | KDM5AKDM4CKDM4EALDH1A1HPGD | |
| SCHEMBL9215707 | 0.82 | DPP4 (0.34) | KDM5AKDM4CKDM4EALDH1A1HPGD | |
| SCHEMBL9213889 | 0.81 | GSK3B (0.36) | KDM5AKDM4CKDM4EALDH1A1HPGD | |
| SCHEMBL6624351 | 0.80 | KDM4E (0.57) | KDM5AKDM4CKDM4EALDH1A1HPGD | |
| SCHEMBL8207281 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1HPGDHSD17B10GAA | |
| SCHEMBL5438939 | 0.76 | CDK2 (0.48) | KDM5AKDM4CKDM4EALDH1A1HPGD | |
| SCHEMBL8185805 | 0.74 | POLB (0.40) | KDM4EALDH1A1HSD17B10KMT2AGAA | |
| SCHEMBL9211680 | 0.74 | KDM4E (0.48) | KDM5AKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5826567 | 0.73 | MAPT (0.37) | KDM4EALDH1A1HPGDHSD17B10KMT2A | |
| SCHEMBL8184450 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369145-B1 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEM IND INC (JP) | 1995-12-27 | — | — | EP | disclosed |
| US-4992442-A | Bronchodilator agents | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0369145-A2 | Pyrrolo[3,2-e]pyrazolo[1,5-a]pyrimidine derivatives and medicines comprising the same | POLA CHEMICAL INDUSTRIES INC., JAPAN (JP) | 1990-05-23 | — | — | EP | disclosed |