Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3012625 | 0.84 | ALDH1A1 (0.66) | NPC1MAPTKMT2AATMALDH1A1 | |
| SCHEMBL22777908 | 0.84 | MAPT (0.73) | NPC1MAPTRECQLKMT2AATM | |
| SCHEMBL3588245 | 0.83 | ATM (0.56) | NPC1MAPTKMT2AATMCHRNB2 | |
| SCHEMBL21834187 | 0.81 | ATM (0.54) | NPC1MAPTKMT2AATMALDH1A1 | |
| SCHEMBL3763356 | 0.78 | HDAC2 (0.56) | — | |
| SCHEMBL11727522 | 0.76 | TERT (0.55) | NPC1MAPTKMT2AATMALDH1A1 | |
| SCHEMBL11756465 | 0.76 | ATM (0.46) | NPC1MAPTKMT2AATMALDH1A1 | |
| SCHEMBL11756458 | 0.76 | ATM (0.46) | NPC1MAPTKMT2AATMALDH1A1 | |
| SCHEMBL23962421 | 0.75 | NPC1 (0.53) | NPC1KMT2AATMCHRNB2SLC6A2 | |
| Water SCHEMBL11729710 | 0.75 | TERT (0.54) | NPC1MAPTKMT2AATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000027827-A1 | OXAZOLIDINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-18 | — | — | WO | disclosed |