Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30555364 | 0.84 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL22777990 | 0.84 | MAPT (0.75) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL8207310 | 0.84 | NPC1 (0.60) | MAPTALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL5970133 | 0.83 | MAPT (0.66) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL3012625 | 0.83 | ALDH1A1 (0.66) | MAPTALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL3588245 | 0.82 | ATM (0.56) | MAPTALDH1A1NPSR1KMT2AKDM4E | |
| SCHEMBL21834187 | 0.79 | ATM (0.54) | MAPTALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL6689700 | 0.78 | GFER (1.00) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL28139220 | 0.77 | MAPT (0.69) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 | |
| SCHEMBL975489 | 0.76 | MAPT (1.00) | MAPTALDH1A1NPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-11-10 | — | — | US | disclosed |
| WO-2020252130-A1 | KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252130-A1 | KV11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | LIEBER INSTITUTE, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220356176-A1 | Kv11.1-3.1 INHIBITING METHODS AND COMPOSITIONS | KCNAB1, KCNMA1, KCNA1 | MAPT 2623/4885ALDH1A1 1489/4885NPSR1 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.