Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8205766 | 0.90 | GAA (0.38) | GAASMN1; SMN2HTR2BHTTKDM4E | |
| SCHEMBL8209367 | 0.87 | GAA (0.39) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8207365 | 0.83 | FNTA (0.40) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8207539 | 0.83 | PTGDR2 (0.35) | GAASMN1; SMN2HTR2BHTTKDM4E | |
| SCHEMBL8206760 | 0.78 | KDM4E (0.38) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8199294 | 0.77 | GAA (0.35) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL7241462 | 0.77 | CYP19A1 (0.41) | — | |
| SCHEMBL7241459 | 0.77 | CYP19A1 (0.41) | — | |
| SCHEMBL8199405 | 0.76 | NTRK1 (0.36) | GAASMN1; SMN2HTTKDM4EMEN1 | |
| SCHEMBL8205725 | 0.75 | EIF4E (0.33) | GAASMN1; SMN2HTR2BCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |