Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | UNG | P13051 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | RBBP9 | O75884 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206760 | 0.88 | KDM4E (0.38) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8207364 | 0.87 | GAA (0.38) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8207251 | 0.82 | MRGPRX4 (0.38) | GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL8207539 | 0.81 | PTGDR2 (0.35) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8199698 | 0.81 | FNTA (0.46) | ALDH1A1MEN1KMT2A | |
| SCHEMBL8206086 | 0.81 | GAA (0.43) | GAASMN1; SMN2HTTKDM4EUNG | |
| SCHEMBL8199405 | 0.80 | NTRK1 (0.36) | GAASMN1; SMN2HTTKDM4EMEN1 | |
| SCHEMBL8205766 | 0.79 | GAA (0.38) | GAASMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL8205725 | 0.77 | EIF4E (0.33) | GAASMN1; SMN2RBBP9CYP1A2CYP2D6 | |
| SCHEMBL8199294 | 0.76 | GAA (0.35) | GAASMN1; SMN2HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |