Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | PLAUR | Q03405 | 2/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL8207726 | 0.87 | BACE1 (0.33) | BACE1THRBMMP2KMT2A | |
| Phenylalanine SCHEMBL6707280 | 0.87 | THRB (0.37) | BACE1THRBMMP2PLAUPLAUR | |
| Tryptophan SCHEMBL8831012 | 0.85 | PTH1R (0.41) | KMT2APTH1R | |
| Dl-Phenylalanine SCHEMBL28430093 | 0.83 | ALPI (0.41) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL2502333 | 0.83 | BACE1 (0.40) | BACE1THRBMMP2PLAUPLAUR | |
| Dl-Phenylalanine SCHEMBL28197596 | 0.82 | THRB (0.46) | THRBMMP2ALPIPKMPTGS1 | |
| Dl-Phenylalanine SCHEMBL28104359 | 0.82 | ALPI (0.46) | BACE1THRBMMP2PLAUPLAUR | |
| Tyrosine SCHEMBL9170935 | 0.81 | SLC7A5 (0.43) | THRBSLC7A5KMT2A | |
| Dl-Phenylalanine SCHEMBL29136216 | 0.81 | ANPEP (0.45) | THRBMMP2PLAUPLAURALPI | |
| Arginine SCHEMBL29194956 | 0.80 | TFPI (0.40) | PTH1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150153-A | PURE CULTURE OF SULFOLOBUS AND MUTANTS HAVING AT LEAST 0.03 UNIT/ML OF ENZYME ACTIVITY; FOR HYDROLASE ENZYME USED IN MANUFACTURE OF FOODS, COSMETICS, DRUGS | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2000-11-21 | — | — | US | disclosed |
| EP-0688866-B1 | Thermostable trehalose-releasing enzyme, and its preparation and uses | HAYASHIBARA BIOCHEM LAB (JP) | 1998-09-09 | — | — | EP | disclosed |
| US-5723327-A | HYDROLYZES OLIGO- AND POLYSACCHARIDES WITH TREHALOSE END UNIT; CULTURING SULFOBUS; FOODS, COSMETICS, DRUGS | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0688866-A1 | Thermostable trehalose-releasing enzyme, and its preparation and uses | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 1995-12-27 | — | — | EP | disclosed |