SCHEMBL8207737

SCHEMBL8207737

CC(=NOC(C)c1ccccc1)OCc1ccccc1C(=CC(F)(F)F)C(=O)O

nearest known ligand 0.31

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
HCAR2 Q8TDS4 1/20 0.30
PPARG P37231 1/20 0.30
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8207734 1.00 KDM4E (0.31) KDM4EALDH1A1LMNAHCAR2PPARG
SCHEMBL8200865 0.88 HCAR2 (0.33) KDM4EALDH1A1LMNAHCAR2
SCHEMBL8200860 0.88 HCAR2 (0.33) KDM4EALDH1A1LMNAHCAR2
SCHEMBL8209012 0.81 SLC6A2 (0.31) HCAR2
SCHEMBL8207824 0.77 HIF1A (0.33) KDM4EALDH1A1LMNA
SCHEMBL8201571 0.71 FOLH1 (0.33) ALDH1A1LMNA
SCHEMBL8201573 0.71 FOLH1 (0.33) ALDH1A1LMNA
SCHEMBL8200862 0.68 HCAR2 (0.33) HCAR2
SCHEMBL8201445 0.67 MIF (0.38) PPARGPPARA
SCHEMBL8209462 0.66 MMP8 (0.41) KDM4EALDH1A1LMNAHCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1021399-A2 FUNGICIDES WITH HYDROXIMIC AND HYDRAZONIC GROUPS AVENTIS CROPSCIENCE S.A. (FR) 2000-07-26 EP disclosed
WO-1998015512-A2 FUNGICIDES WITH HYDROXIMIC AND HYDRAZONIC GROUPS RHONE POULENC AGROCHIMIE (FR) 1998-04-16 WO disclosed