Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 8/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 8/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14947619 | 0.85 | GPR119 (0.46) | POLBKCNK3KCNK9GPR119CHRM2 | |
| SCHEMBL2592119 | 0.83 | CHRM2 (0.48) | KCNK3KCNK9GPR119CHRM2CHRM1 | |
| SCHEMBL2583990 | 0.83 | GPR119 (0.48) | POLBKCNK3KCNK9GPR119CHRM2 | |
| SCHEMBL2587471 | 0.81 | GPR119 (0.46) | KCNK3KCNK9GPR119CHRM2CHRM1 | |
| SCHEMBL2587863 | 0.81 | GPR119 (0.48) | POLBKCNK3KCNK9GPR119CHRM2 | |
| SCHEMBL2586854 | 0.80 | GPR119 (0.42) | KCNK3KCNK9GPR119CHRM2CHRM1 | |
| SCHEMBL2591601 | 0.79 | OPRM1 (0.49) | KCNK3KCNK9GPR119CHRM2CHRM1 | |
| SCHEMBL6500038 | 0.78 | GAA (0.61) | GPR119CHRM2CHRM1CHRM3 | |
| SCHEMBL6500041 | 0.78 | GAA (0.61) | GPR119CHRM2CHRM1CHRM3 | |
| SCHEMBL2590190 | 0.78 | CHRM2 (0.45) | KCNK3KCNK9GPR119CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971918-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998046600-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-10-22 | — | — | WO | disclosed |