Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL971856 | 0.83 | ALDH1A1 (0.43) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL1342303 | 0.82 | ALDH1A1 (0.63) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL30072983 | 0.81 | TDP1 (0.60) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL1059260 | 0.81 | ALDH1A1 (0.67) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL8229692 | 0.80 | TDP1 (0.48) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL2841769 | 0.80 | TDP1 (0.48) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL1340836 | 0.77 | L3MBTL1 (0.68) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL29254173 | 0.77 | ALDH1A1 (0.57) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL15283229 | 0.77 | TDP1 (0.44) | TDP1MEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL2418024 | 0.76 | TDP1 (0.45) | TDP1MEN1MAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6110961-A | USEFUL IN PROPHYLAXIS AND TREATMENT OF MENTAL DISORDERS, SUCH AS DEPRESSION, ANXIETY | KRENITSKY PHARMACEUTICALS, INC. (US) | 2000-08-29 | — | — | US | disclosed |
| EP-1021434-A2 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND USE | Krenitsky Pharmaceuticals, Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1998012190-A2 | PHENOXATHIIN DERIVATIVES AS INHIBITORS OF MONOAMINE OXIDASE | KRENITSKY PHARMACEUTICAL, INC. (US) | 1998-03-26 | — | — | WO | disclosed |