SCHEMBL8208263

SCHEMBL8208263

N#CCCC(CO)(CCC#N)CCC#N

nearest known ligand 0.39

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
TDP1 Q9NUW8 1/20 0.39
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TSHR P16473 4/20 0.32
LOX P28300 1/20 0.32
LOXL3 P58215 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.32
CYP3A4 P08684 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13437589 0.88 TSHR (0.39) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL7543839 0.85 MEN1 (0.39) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL13403168 0.82 MEN1 (0.32) MEN1KMT2A
SCHEMBL17935652 0.81 ALDH1A1 (0.50) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL13423985 0.76 ALDH1A1 (0.33) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL4854212 0.74 ALDH1A1 (0.37) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL8485451 0.72
SCHEMBL25729216 0.71 TSHR (0.41) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL18429071 0.71 LOX (0.45) ALDH1A1TDP1MEN1KMT2ATSHR
SCHEMBL12123460 0.69 ALDH1A1 (0.35) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9822134-B2 System for delivering therapeutic agents into living cells and cells nuclei SABAG-RFA LTD. (IL) 2017-11-21 US disclosed
US-9556210-B2 System for delivering therapeutic agents into living cells and cells nuclei SABAG-RFA LTD. (IL) 2017-01-31 US disclosed
US-20160176903-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI SABAG-RFA LTD. (IL) 2016-06-23 US disclosed
US-20160039850-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI SABAG-RFA LTD. (IL) 2016-02-11 US disclosed
US-9156865-B2 System for delivering therapeutic agents into living cells and cells nuclei DELIVERSIR LTD (IL) 2015-10-13 US disclosed
WO-2014064687-A1 A SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI DELIVERSIR LTD (IL) 2014-05-01 WO disclosed
US-20130137755-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI SEGEV LABORATORIES LIMITED (IL) 2013-05-30 US disclosed
US-8293209-B2 System for delivering therapeutic agents into living cells and cells nuclei SEGEV LABORATORIES LIMITED (IL) 2012-10-23 US disclosed
US-20100104512-A1 Dendritic Chelated Compounds, Methods for Making the Same and Pharmaceutical Compositions Containing the Same CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-04-29 US disclosed
US-20100092386-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI SABAG-RFA LTD. (IL) 2010-04-15 US disclosed
WO-2008043911-A2 DENDRITIC CHELATED COMPOUNDS, METHODS FOR MAKING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2008-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160039850-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI NFATC1, KPNA2, KPNA6 ALDH1A1 4566/4885TDP1 1114/4885MEN1 1510/4885
US-20100092386-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI NFATC1, KPNA2, KPNA6 ALDH1A1 4566/4885TDP1 1114/4885MEN1 1510/4885
US-20130137755-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI NFATC1, KPNA2, KPNA6 ALDH1A1 4566/4885TDP1 1114/4885MEN1 1510/4885
US-20160176903-A1 SYSTEM FOR DELIVERING THERAPEUTIC AGENTS INTO LIVING CELLS AND CELLS NUCLEI NFATC1, KPNA2, KPNA6 ALDH1A1 4566/4885TDP1 1114/4885MEN1 1510/4885
US-20100104512-A1 Dendritic Chelated Compounds, Methods for Making the Same and Pharmaceutical Compositions Containing the Same ZYX, CXCR4, ZFX ALDH1A1 4611/4885TDP1 4286/4885MEN1 398/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.