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Sugi Predict / Targets / KPNA6

KPNA6

Importin subunit alpha-7 · O60684 · KPNA6 on Sugi Atlas →

1,892 patent compounds predicted against KPNA6, 1,675 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Molibresib Molibresib (SCHEMBL1872390) 1.00 1/20
Molibresib Molibresib (SCHEMBL12671490) 1.00 1/20
Molibresib Molibresib (SCHEMBL12966358) 1.00 1/20
SCHEMBL9998851 SCHEMBL9998851 0.91 1/20
SCHEMBL14756282 SCHEMBL14756282 0.88 1/20
SCHEMBL15980874 SCHEMBL15980874 0.88 1/20
SCHEMBL12966165 SCHEMBL12966165 0.87 1/20
SCHEMBL14756215 SCHEMBL14756215 0.87 1/20
SCHEMBL14756339 SCHEMBL14756339 0.87 1/20
SCHEMBL15980861 SCHEMBL15980861 0.87 1/20
SCHEMBL9998825 SCHEMBL9998825 0.86 1/20
SCHEMBL15980893 SCHEMBL15980893 0.86 1/20
SCHEMBL15980803 SCHEMBL15980803 0.86 1/20
SCHEMBL1874116 SCHEMBL1874116 0.85 1/20
SCHEMBL12671221 SCHEMBL12671221 0.85 1/20
SCHEMBL14756021 SCHEMBL14756021 0.85 1/20
SCHEMBL14756240 SCHEMBL14756240 0.85 1/20
SCHEMBL14756287 SCHEMBL14756287 0.85 1/20
SCHEMBL14756335 SCHEMBL14756335 0.85 1/20
SCHEMBL14756409 SCHEMBL14756409 0.85 1/20

Clinical trials — most relevant to KPNA6 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection PHASE3COMPLETED
Selinexor With ICE Chemotherapy in Secondary Central Nervous System Involving B-cell Non-Hodgkin Lymphoma PHASE1/PHASE2RECRUITING
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria PHASE2COMPLETED
A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL PHASE1/PHASE2RECRUITING
Efficacy of Ivermectin in COVID-19 PHASE1/PHASE2COMPLETED
A Clinical Study on the Efficacy and Safety of Methotrexate (MTX) or Thiotepa (for MTX Intolerance) or Temozolomide (TMZ) Combined With Orelabrutinib and Selinexor in Relapsed/Refractory Primary or Secondary Central Nervous System Lymphoma（SELINA） nanRECRUITING
Quantitative Assessment of the Etiologies of Megalencephaly Associated With a Detectable Tumor Risk nanNOT_YET_RECRUITING
Mechanisms of Resistance to Amivantamab in Patients With NSCLC With EGFR Exon 20 Insertion nanRECRUITING
Molecular Genetics Study of Nasopharyngeal Carcinoma: Characterization of NCP Susceptibility Gene(s) nanCOMPLETED
A Study on the Prevalence of Mutation of Cerebrotendinous Xanthomatosis (CTX) nanUNKNOWN
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Chordoma Family Study nanCOMPLETED
Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis nanCOMPLETED
Genetic Analysis of Gray Platelet Syndrome nanCOMPLETED
Genetic Bases of Neuroendocrine Neoplasms in Mexican Patients nanRECRUITING
Biomarker for Niemann Pick Type C Disease (BioNPC) nanWITHDRAWN
Study of The Association of Mutations in The NPHS2 Gene and Nephrotic Syndrome in Children and Adults in Middle East nanUNKNOWN
Induced Pluripotent Stem Cells for Niemann Pick Disease nanCOMPLETED
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo) nanWITHDRAWN
Genetic Causes and Clinical Features of Childhood Interstitial Lung Diseases in China nanCOMPLETED
Mackenzie's Mission: The Australian Reproductive Carrier Screening Project nanCOMPLETED
Genetic Investigation of Cancer Predisposition nanNOT_YET_RECRUITING
Identification of Genetic Factors Implicated in Orofacial Cleft Using Whole Exome Sequencing nanRECRUITING
Phenotypic and Genotypic Studies in Congenital and Early Onset Ataxias nanCOMPLETED
Steroid Treatment of Idiopathic Nephrotic Syndrome nanCOMPLETED
Genetic Analysis of Hereditary Disorders of Hearing and Balance nanCOMPLETED
Bile Acid Effects in Fetal Arrhythmia Study nanUNKNOWN
Dried Fruit and Postprandial Glycemia Trial nanUNKNOWN
Inter-regional Project of the Great Western Exploration Approach for Exome Molecular Causes Severe Intellectual Disability Isolated or Syndromic nanCOMPLETED
Genetics of Ehlers-Danlos Syndrome nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a KPNA6 binder may also engage these)

ProteinNameSimilarity
Q5RBV0 — 1.000 Q5RBV0 →
Q0V7M0 — 1.000 Q0V7M0 →
O35345 — 1.000 O35345 →
O15131 — 1.000 O15131 →
Q503E9 — 1.000 Q503E9 →
KPNA1 Importin subunit alpha-5 1.000 landscape →
A2VE08 — 0.999 A2VE08 →
Q5R909 — 0.999 Q5R909 →
Q60960 — 0.997 Q60960 →
Q5ZML1 — 0.996 Q5ZML1 →
P83953 — 0.995 P83953 →
Q56R16 — 0.985 Q56R16 →
P18484 — 0.943 P18484 →
P17427 — 0.943 P17427 →
E2R222 — 0.943 E2R222 →
Q5R874 — 0.942 Q5R874 →
P20595 — 0.941 P20595 →
O70133 — 0.941 O70133 →
P52297 — 0.941 P52297 →
E1C6Q1 — 0.939 E1C6Q1 →
O88544 — 0.939 O88544 →
AP2A2 AP-2 complex subunit alpha-2 0.938 landscape →
Q5F418 — 0.938 Q5F418 →
DHX9 ATP-dependent RNA helicase A 0.938 landscape →
Q6NRT5 — 0.938 Q6NRT5 →
Q9BQ87 — 0.937 Q9BQ87 →
D3K5L7 — 0.937 D3K5L7 →
P70188 — 0.937 P70188 →
O54865 — 0.937 O54865 →
AP2A1 AP-2 complex subunit alpha-1 0.937 landscape →