SCHEMBL8208536

SCHEMBL8208536

Clc1ccc2ccccc2c1.Clc1cccc2ccccc12

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 6/20 0.68
CYP1A2 P05177 5/20 0.68
FADS1 O60427 1/20 0.43
ALDH1A1 P00352 2/20 0.42
HSD17B10 Q99714 2/20 0.42
TSHR P16473 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
CYP1B1 Q16678 3/20 0.41
HIF1A Q16665 1/20 0.41
MAPT P10636 3/20 0.41
LMNA P02545 1/20 0.41
HTT P42858 1/20 0.41
KDM4E B2RXH2 1/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
GAA P10253 1/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 1/20 0.41
CYP1A1 P04798 2/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL145859 1.00 CYP2A6 (0.68) CYP2A6CYP1A2FADS1ALDH1A1HSD17B10
Chlorobenzene SCHEMBL28112104 0.94 CYP1A2 (0.61) CYP2A6CYP1A2FADS1ALDH1A1HSD17B10
Methyl Alcohol SCHEMBL28240100 0.94 CYP2A6 (0.61) CYP2A6CYP1A2FADS1ALDH1A1HSD17B10
Acetone SCHEMBL28077025 0.90 CYP2A6 (0.55) CYP2A6CYP1A2ALDH1A1TDP1CYP1B1
Phenol SCHEMBL6410569 0.90 CYP2A6 (0.55) CYP2A6CYP1A2TSHRMAPTLMNA
Dimethylformamide SCHEMBL28302419 0.86 CYP2A6 (0.50) CYP2A6CYP1A2FADS1CYP1B1MAPT
Naphthalene SCHEMBL8141546 0.85 CYP2A6 (0.94) CYP2A6CYP1A2ALDH1A1HSD17B10TSHR
SCHEMBL1780245 0.83 CYP1A2 (0.58) CYP2A6CYP1A2FADS1ALDH1A1TSHR
SCHEMBL30366567 0.83 CYP2A6 (0.58) CYP2A6CYP1A2FADS1ALDH1A1HSD17B10
SCHEMBL6561452 0.83 CYP2A6 (0.58) CYP2A6CYP1A2FADS1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0703281-B1 Process for the manufacture of brominated, alkoxy substituted metal phthalocyanine CIBA SC HOLDING AG (CH) 2000-03-01 EP claimed
EP-0703281-A1 Process for the manufacture of brominated, alkoxy substituted metal phthalocyanine CIBA-GEIGY AG (CH) 1996-03-27 EP claimed
US-4052221-A CHLORINATED NAPTHALENE, PARATERPHENYL, SEMICONDUCTOR WAFER WESTERN ELECTRIC COMPANY, INC. (US) 1977-10-04 US disclosed