Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.64 |
| ▸ | HTR2B | P41595 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 13/20 | 0.51 |
| ▸ | HTR1D | P28221 | 4/20 | 0.40 |
| ▸ | HTR1B | P28222 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR1E | P28566 | 2/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14051801 | 0.87 | HTR1A (0.61) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL14001604 | 0.86 | HTR1A (0.60) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL10108909 | 0.86 | HTR1A (0.60) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL9688555 | 0.83 | HTR6 (0.57) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL917269 | 0.82 | HTR6 (0.56) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL9688466 | 0.81 | HTR1A (0.60) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Fumaric Acid SCHEMBL1851452 | 0.80 | HTR1A (0.54) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Fumaric Acid SCHEMBL1851455 | 0.80 | HTR1A (0.54) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| SCHEMBL1851454 | 0.80 | HTR1A (0.53) | HTR1AHTR2AHTR2BLMNAADRA2B | |
| Almotriptan SCHEMBL3273179 | 0.78 | HTR1A (1.00) | HTR1AHTR2AHTR2BLMNAADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008097546-A2 | COMPOUNDS THAT INHIBIT CHOLINESTERASE | COLUCID PHARMACEUTICALS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |