Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.60 |
| ▸ | HTR1B | P28222 | 3/20 | 0.60 |
| ▸ | HTR7 | P34969 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | HTR2B | P41595 | 3/20 | 0.60 |
| ▸ | HTR1E | P28566 | 2/20 | 0.60 |
| ▸ | HTR1F | P30939 | 2/20 | 0.60 |
| ▸ | HTR5A | P47898 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | HTR3A | P46098 | 1/20 | 0.60 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 16/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688555 | 0.86 | HTR6 (0.57) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL9687324 | 0.86 | HTR1A (0.57) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL917269 | 0.85 | HTR6 (0.56) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL10109312 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL13651695 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| Hydrochloric Acid SCHEMBL9687692 | 0.85 | HTR1A (0.56) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL9597932 | 0.84 | HTR1A (0.55) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL9687900 | 0.84 | HTR1A (0.55) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL9597530 | 0.82 | HTR1A (0.53) | HTR1AHTR1DHTR1BHTR7HTR2A | |
| SCHEMBL9765127 | 0.82 | HTR6 (0.61) | HTR1AHTR1DHTR1BHTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992014708-A1 | INDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1992-09-03 | — | — | WO | disclosed |
| EP-0500086-A1 | Indole derivatives, their use as medicines and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |