Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitrobenzene SCHEMBL9324297 | 0.91 | ALDH1A1 (0.70) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Nitrobenzene SCHEMBL6398341 | 0.89 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Nitrobenzene SCHEMBL28135666 | 0.87 | LMNA (0.70) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| Nitrobenzene SCHEMBL27737077 | 0.85 | ALDH1A1 (0.73) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| Nitrobenzene SCHEMBL28306081 | 0.82 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Nitrobenzene SCHEMBL28084244 | 0.82 | ALDH1A1 (0.57) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| SCHEMBL27812257 | 0.81 | MAPT (0.50) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Nitrobenzene SCHEMBL27798660 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Nitrobenzene SCHEMBL27867788 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKCNH2KMT2A | |
| Octadecylamine SCHEMBL10745393 | 0.81 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071935-A | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0907649-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049700-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |