SCHEMBL8208767

SCHEMBL8208767

c1ccc(C(NNc2ccc3ccccc3c2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
CYP3A4 P08684 2/20 0.50
HSD17B10 Q99714 2/20 0.50
HPGD P15428 1/20 0.50
CYP1A2 P05177 3/20 0.46
CYP2C19 P33261 2/20 0.46
HIF1A Q16665 2/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
KDM4E B2RXH2 5/20 0.44
LMNA P02545 4/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
GAA P10253 3/20 0.44
HTT P42858 1/20 0.44
MAPT P10636 5/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
MEN1 O00255 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9172014 0.78 ALDH1A1 (0.52) ALDH1A1CYP3A4HSD17B10CYP1A2CYP2C19
SCHEMBL1648784 0.77 ALDH1A1 (0.62) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL80985 0.76 ALDH1A1 (0.68) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL21839329 0.70 KCNN4 (0.60) ALDH1A1HSD17B10CYP1A2KCNN4MAPK1
SCHEMBL16738043 0.69 FFAR1 (0.49) ALDH1A1NPC1RAB9AMEN1KMT2A
SCHEMBL3739909 0.68 ALDH1A1 (0.86) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL182655 0.68 ALDH1A1 (0.86) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL29386674 0.68 ALDH1A1 (0.86) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL11802411 0.68 ALDH1A1 (0.67) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2
SCHEMBL11466814 0.67 ALDH1A1 (1.00) ALDH1A1CYP3A4HSD17B10HPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6096144-A TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2000-08-01 US disclosed
US-5858571-A TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-01-12 US disclosed
US-4758639-A Process for production of vinyl polymer SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-19 US disclosed
US-4757124-A Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments SHIN-ETSU CHEMICAL CO., LTD. (JP) 1988-07-12 US disclosed
EP-0172427-A2 Process for production of vinyl chloride polymer Shin-Etsu Chemical Co., Ltd. (JP) 1986-02-26 EP disclosed