SCHEMBL8209092

SCHEMBL8209092

c1ccc(CCCc2ccc(P(c3ccc(CCCc4ccccc4)cc3)c3ccc4ccccc4c3-c3c(P(c4ccc(CCCc5ccccc5)cc4)c4ccc(CCCc5ccccc5)cc4)ccc4ccccc34)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
KMT2A Q03164 1/20 0.37
GPR84 Q9NQS5 1/20 0.37
MAOB P27338 2/20 0.36
KCNH2 Q12809 1/20 0.36
CYP1A1 P04798 1/20 0.35
CYP1B1 Q16678 1/20 0.35
SIGMAR1 Q99720 1/20 0.35
IDO1 P14902 1/20 0.35
HTR1A P08908 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7902294 0.88 GAA (0.39) CYP1A2CYP2D6CYP2C19
SCHEMBL8203452 0.85 CYP1A2 (0.36) CYP1A2CYP2D6CYP2C19KMT2AGPR84
SCHEMBL24779295 0.83 TRPV1 (0.36) SIGMAR1
SCHEMBL10323632 0.82 ALDH1A1 (0.44) CYP1A2GPR84CYP1B1
SCHEMBL29350037 0.82 ALDH1A1 (0.44) CYP1A2GPR84CYP1B1
SCHEMBL146878 0.82 ALDH1A1 (0.44) CYP1A2GPR84CYP1B1
SCHEMBL5107 0.82 ALDH1A1 (0.44) CYP1A2GPR84CYP1B1
SCHEMBL29496111 0.82 ALDH1A1 (0.44) CYP1A2GPR84CYP1B1
SCHEMBL729691 0.80 ALDH1A1 (0.42) CYP1A2GPR84CYP1B1
SCHEMBL3416712 0.80 ALDH1A1 (0.42) CYP1A2GPR84CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6043398-A WATER-SOLUBLE, SULFONATED DIPHOSPHINES COMPLEXED WITH A TRANSITION METAL TO FORM HYDROFORMYLATION CATALYSTS; OUTSTANDING SURFACE ACTIVE PROPERTIES IN TWO PHASE CATALYSIS OF TWO PHASE HYDROFORMYLATION OF OCT-1-ENE OLEFINS CELANESE INTERNATIONAL CORPORATION (US) 2000-03-28 US disclosed
US-5929273-A METALLATION OF ARYLPHOSPHINE HALIDE BY HEATING AND PRESSURIZING IN SUITABLE CONDITIONS TO FORM ARYLPHSPHINIDE, COUPLING THE FORMED INTERMEDIATE WITH ORGANIC HALIDE TO FORM ARYL DIPHOSPHINE CELANESE INTERNATIONAL CORP (US) 1999-07-27 US disclosed
US-5777087-A Aryl diphosphines and catalysts containing the same CELANESE INTERNATIONAL CORPORATION (US) 1998-07-07 US disclosed