Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.49 |
| ▸ | CPB1 | P15086 | 1/20 | 0.49 |
| ▸ | CPA3 | P15088 | 1/20 | 0.49 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8209162 | 1.00 | MMP12 (0.50) | MMP12CPA1CPB1CPA3CPB2 | |
| SCHEMBL2571746 | 0.88 | CPA1 (0.56) | CPA1CPB1CPA3CPB2ALDH1A1 | |
| SCHEMBL973970 | 0.86 | CA1 (0.54) | MMP12CPA1CPB1CPA3CPB2 | |
| SCHEMBL27410141 | 0.85 | CYP1A2 (0.52) | CPA1CPB1CPA3CPB2ALDH1A1 | |
| SCHEMBL9555874 | 0.84 | KMT2A (0.53) | MMP12CPA1CPB1CPA3CPB2 | |
| SCHEMBL1405655 | 0.84 | KMT2A (0.53) | MMP12CPA1CPB1CPA3CPB2 | |
| SCHEMBL28639320 | 0.83 | CPA1 (0.51) | CPA1CPB1CPA3CPB2ALDH1A1 | |
| SCHEMBL7354310 | 0.83 | CPA3 (0.66) | MMP12CPA1CPB1CPA3CPB2 | |
| SCHEMBL25908577 | 0.83 | CPA1 (0.51) | CPA1CPB1CPA3CPB2ALDH1A1 | |
| SCHEMBL8399603 | 0.83 | CPA3 (0.66) | MMP12CPA1CPB1CPA3CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5643908-A | ANGIOGENESIS INHIBITOR, ANTITUMOR | SANKYO COMPANY, LIMITED (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0621270-A1 | COLLAGENASE INHIBITOR | SANKYO COMPANY LIMITED (JP) | 1994-10-26 | — | — | EP | disclosed |