Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208820 | 0.85 | HPGD (0.45) | LMNACA1CA2HPGDALDH1A1 | |
| SCHEMBL8207035 | 0.82 | MEN1 (0.42) | HPGDALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8205741 | 0.75 | PRKAA2 (0.44) | KDM4EALDH1A1HIF1A | |
| SCHEMBL29278807 | 0.72 | CA1 (0.71) | KDM4ELMNACA1CA2HPGD | |
| SCHEMBL21753196 | 0.70 | HPGD (0.79) | LMNACA1CA2HPGDALDH1A1 | |
| SCHEMBL12853188 | 0.70 | CYP2C19 (0.62) | KDM4ELMNACA1CA2ALDH1A1 | |
| SCHEMBL3946632 | 0.67 | HPGD (0.68) | KDM4ECA1CA2HPGDALDH1A1 | |
| SCHEMBL4644151 | 0.67 | RAB9A (0.45) | KDM4EHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL10077694 | 0.67 | HPGD (0.72) | KDM4ECA1CA2HPGDALDH1A1 | |
| SCHEMBL12623587 | 0.65 | HPGD (0.62) | KDM4ELMNACA1CA2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008082487-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |