Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | STAT6 | P42226 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6081184 | 0.80 | MAPK14 (0.45) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL4683728 | 0.73 | HTR7 (0.43) | RAB9ANPC1HTR7ADRA2BADRA2C | |
| SCHEMBL30509718 | 0.70 | HTR7 (0.59) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13402939 | 0.70 | HTR7 (0.59) | RAB9AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8358440 | 0.69 | MMP13 (0.66) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL27862873 | 0.68 | CA1 (0.51) | RAB9ANPC1MEN1KMT2AALDH1A1 | |
| SCHEMBL7700166 | 0.68 | RAB9A (0.70) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL8209567 | 0.67 | KDM4E (0.47) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL21753196 | 0.67 | HPGD (0.79) | KMT2AALDH1A1HPGDMMP13SMN1; SMN2 | |
| SCHEMBL3946632 | 0.66 | HPGD (0.68) | KMT2AMAPTALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1675830-A4 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1675830-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033072-A2 | HETEROCYCLIC AMIDES AND SULFONAMIDES | SCIOS INC. (US) | 2005-04-14 | — | — | WO | disclosed |