SCHEMBL8209632

SCHEMBL8209632

Nc1cccc(CC2CCNC2)n1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NOS1 P29475 3/20 0.48
NOS3 P29474 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14000807 1.00 NOS1 (0.48) NOS1NOS3
SCHEMBL20310263 0.85 HRH4 (0.45)
SCHEMBL28054884 0.81 NOS1 (0.46) NOS1NOS3
SCHEMBL29496121 0.78 MCHR1 (0.44) NOS1NOS3
SCHEMBL2144121 0.78 NOS1 (0.43) NOS1NOS3
SCHEMBL21608098 0.78 EED (0.45)
SCHEMBL21607920 0.78 HTR2C (0.41)
SCHEMBL20281655 0.78 HRH4 (0.39)
SCHEMBL8210420 0.76 NOS1 (0.40) NOS1NOS3
SCHEMBL13064270 0.76 NOS2 (0.52) NOS1NOS3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008042353-A1 POTENT AND HIGHLY SELECTIVE HETEROAROMATIC INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE NORTHWESTERN UNIVERSITY (US) 2008-04-10 WO disclosed