SCHEMBL8209991

SCHEMBL8209991

NC(=O)/C=C(/CC(N)=O)C(=O)O

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.46
TSHR P16473 1/20 0.46
CPB1 P15086 1/20 0.34
ABAT P80404 1/20 0.33
LDHA P00338 1/20 0.32
LDHB P07195 1/20 0.32
GRIK1 P39086 1/20 0.31
GRIK2 Q13002 1/20 0.31
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30173709 1.00 KDM4E (0.46) KDM4ETSHRCPB1ABATLDHA
SCHEMBL7771087 0.92 TSHR (0.52) KDM4ETSHRCPB1ABATLDHA
SCHEMBL7771088 0.92 TSHR (0.52) KDM4ETSHRCPB1ABATLDHA
SCHEMBL1234795 0.85 TSHR (0.65) KDM4ETSHRCPB1ABATLDHA
SCHEMBL28938285 0.85 TSHR (0.65) KDM4ETSHRCPB1ABATLDHA
SCHEMBL4115859 0.85 TSHR (0.65) KDM4ETSHRCPB1ABATLDHA
SCHEMBL30461050 0.85 TSHR (0.65) KDM4ETSHRCPB1ABATLDHA
SCHEMBL15662540 0.82 POLB (0.31) KDM4ETSHRPOLB
SCHEMBL29871199 0.82 POLB (0.31) KDM4ETSHRPOLB
SCHEMBL24180793 0.81 KDM4E (0.43) KDM4ETSHRCPB1ABATGRIK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023156629-A1 STEALTH-STABILIZED LIPO-POLYAMINO ACIDS POLYPEPTIDE THERAPEUTIC SOLUTIONS, S.L. (ES) 2023-08-24 WO disclosed
US-9694085-B2 Targeted therapeutic nanoparticles NANODERM SCIENCES, INC. (US) 2017-07-04 US disclosed
US-20160106852-A1 TARGETED THERAPEUTIC NANOPARTICLES NANODERM SCIENCES, INC. (US) 2016-04-21 US disclosed
US-8470776-B2 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof AETERNA ZENTARIS GMBH (DE) 2013-06-25 US disclosed
EP-1900742-A1 Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof AEterna Zentaris GmbH (DE) 2008-03-19 EP disclosed
WO-2008028934-A1 CONJUGATES OF DISORAZOLES AND THEIR DERIVATIVES WITH CELL-BINDING MOLECULES, NOVEL DISORAZOLE DERIVATIVES, PROCESSES OF MANUFACTURING AND USES THEREOF AETERNA ZENTARIS GMBH (DE) 2008-03-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160106852-A1 TARGETED THERAPEUTIC NANOPARTICLES CD44, PHOSPHO1, CD47 KDM4E 4729/4885TSHR 2364/4885CPB1 2765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.