⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10900189 | 0.82 | — | — | |
| SCHEMBL23668191 | 0.78 | HTR1A (0.31) | — | |
| SCHEMBL27736992 | 0.76 | CHRM2 (0.31) | — | |
| SCHEMBL27896230 | 0.76 | NCF1 (0.31) | — | |
| SCHEMBL18390314 | 0.73 | MC4R (0.32) | — | |
| SCHEMBL7036171 | 0.72 | MAPT (0.33) | — | |
| SCHEMBL9122968 | 0.69 | — | — | |
| SCHEMBL4161986 | 0.69 | CHRM2 (0.33) | — | |
| SCHEMBL14097051 | 0.68 | MAPT (0.34) | — | |
| SCHEMBL9262612 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100262-A | MORPHOLINE RING NITROGEN IS SUBSTITUTED WITH A GROUP HAIVNG A CARBONYL FUNCTIONALITY; FAVOURABLE GASTROINTESTINAL MOTILITY STIMULATING PROPERTIES, THEY ACCELERATE GASTRIC EMPTYING | JANSSEN PHARMACEUTICA, NV. (BE) | 2000-08-08 | — | — | US | disclosed |
| EP-0827500-A1 | (2-MORPHOLINYLMETHYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996037486-A1 | (2-MORPHOLINYLMETHYL)BENZAMIDE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-11-28 | — | — | WO | disclosed |