Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.54 |
| ▸ | APOB | P04114 | 10/20 | 0.54 |
| ▸ | SMO | Q99835 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210367 | 0.88 | MTTP (0.52) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8206850 | 0.88 | MTTP (0.58) | MTTPAPOBSMOKDM4ERXFP1 | |
| SCHEMBL8208396 | 0.87 | APOB (0.56) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8472708 | 0.77 | APOB (0.52) | MTTPAPOBSMOKDM4E | |
| SCHEMBL6645543 | 0.76 | MTTP (0.61) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8211359 | 0.75 | MTTP (0.56) | MTTPAPOBSMOKDM4E | |
| Hydrochloric Acid SCHEMBL6803931 | 0.75 | MTTP (0.60) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8208303 | 0.75 | APOB (0.62) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8227456 | 0.74 | MTTP (0.55) | MTTPAPOBSMOKDM4E | |
| SCHEMBL8230812 | 0.74 | MTTP (0.55) | MTTPAPOBSMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | claimed |
| EP-0944602-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1999-09-29 | — | — | EP | claimed |
| WO-1998023593-A1 | APO B-SECRETION/MTP INHIBITORY AMIDES | PFIZER INC. (US) | 1998-06-04 | — | — | WO | claimed |
| US-6121283-A | Apo B-secretion/MTP inhibitory amides | PFIZER INC (US) | 2000-09-19 | — | — | US | disclosed |