Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11926124 | 0.89 | KLKB1 (0.41) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL8222594 | 0.87 | PIK3CA (0.43) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL8211534 | 0.85 | KLKB1 (0.41) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL8212640 | 0.85 | PIK3CA (0.51) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL11925988 | 0.84 | RAB9A (0.52) | EPHX1RAB9AGAANPC1ALDH1A1 | |
| SCHEMBL8214361 | 0.83 | PIK3CA (0.47) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL8212700 | 0.82 | KLKB1 (0.44) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL8205208 | 0.82 | PIK3CA (0.42) | KLKB1PIK3CAMTOREPHX1RAB9A | |
| SCHEMBL11926130 | 0.81 | PIK3CA (0.41) | PIK3CAMTOREPHX1RAB9ANPC1 | |
| SCHEMBL8220939 | 0.81 | KLKB1 (0.44) | KLKB1PIK3CAMTOREPHX1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |