Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | LIPA | P38571 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4728809 | 0.89 | KEAP1 (0.41) | TSHRALDH1A1EPHX1GRM2CES2 | |
| SCHEMBL14473686 | 0.87 | EPHX1 (0.39) | TSHRALDH1A1EPHX1CES2MAPT | |
| SCHEMBL29122810 | 0.87 | EPHX1 (0.39) | TSHRALDH1A1EPHX1CES2MAPT | |
| SCHEMBL9827947 | 0.77 | — | — | |
| SCHEMBL1427209 | 0.77 | TSHR (0.40) | TSHRALDH1A1EPHX1GRM2GLA | |
| SCHEMBL18483080 | 0.74 | — | — | |
| SCHEMBL5970598 | 0.74 | GRM2 (0.31) | GRM2 | |
| SCHEMBL30018162 | 0.73 | TSHR (0.57) | TSHRALDH1A1GRM2CYP2D6CYP2C19 | |
| SCHEMBL5323379 | 0.72 | — | — | |
| SCHEMBL15619605 | 0.72 | ALDH1A1 (0.36) | TSHRALDH1A1EPHX1GRM2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109898-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF | SHANGHAI HAIYAN PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2024-04-04 | — | — | US | disclosed |
| EP-4282868-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | Shanghai Haiyan Pharmaceutical Technology Co., Ltd (CN) | 2023-11-29 | — | — | EP | disclosed |
| WO-2023202664-A1 | SMALL MOLECULE IL-17A MODULATORS | BEIGENE, LTD. (KY) | 2023-10-26 | — | — | WO | disclosed |
| CN-116761609-A | Substituted pyrazolo [1,5-a ] pyrimidin-7-amine derivatives, compositions thereof and pharmaceutical uses thereof | 上海海雁医药科技有限公司 | 2023-09-15 | — | — | CN | disclosed |
| WO-2022156779-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVE, AND COMPOSITIONS AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2022-07-28 | — | — | WO | disclosed |
| WO-2011033047-A1 | CARBINOLS HAVING OLFACTORY PROPERTIES REMINISCENT OF PATCHOULI OIL | GIVAUDAN SA (CH) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109898-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE-7-AMINE DERIVATIVES, COMPOSITIONS AND PHARMACEUTICAL USES THEREOF | CDK9, CDK19, CDK7 | TSHR 3370/4885ALDH1A1 1590/4885EPHX1 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.