Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 14/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186872 | 0.91 | ALDH1A1 (0.39) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4177678 | 0.88 | ALDH1A1 (0.46) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4194402 | 0.88 | NPBWR1 (0.47) | ALDH1A1KMT2ANPSR1NPBWR1MCHR1 | |
| SCHEMBL4182676 | 0.83 | THRB (0.40) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4199448 | 0.80 | ALDH1A1 (0.42) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4189033 | 0.79 | NPBWR1 (0.51) | ALDH1A1KMT2ANPSR1SMN1; SMN2NPBWR1 | |
| SCHEMBL4184539 | 0.78 | MCHR1 (0.42) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4191767 | 0.78 | NPBWR1 (0.41) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL11566580 | 0.77 | ALDH1A1 (0.54) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 | |
| SCHEMBL4176781 | 0.76 | ALDH1A1 (0.53) | ALDH1A1KMT2ANPSR1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1007515-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | Abbott Laboratories (US) | 2000-06-14 | — | — | EP | disclosed |
| WO-1999010331-A1 | ARYLPYRIDAZINONES AS PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-03-04 | — | — | WO | disclosed |