Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexylamine SCHEMBL7801498 | 0.86 | NPC1 (0.41) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| Water SCHEMBL29120229 | 0.82 | EGFR (0.52) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL7047 | 0.82 | EGFR (0.52) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL28598774 | 0.80 | EGFR (0.50) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL28162772 | 0.77 | CTBP2 (0.49) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| Benzaldehyde SCHEMBL8212619 | 0.77 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTL3MBTL1KMT2A | |
| SCHEMBL3006203 | 0.77 | EGFR (0.47) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL5718152 | 0.77 | FBP1 (0.55) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL5718150 | 0.77 | FBP1 (0.55) | EGFRALDH1A1LMNAMAPTL3MBTL1 | |
| SCHEMBL3189884 | 0.77 | HDAC2 (0.53) | EGFRALDH1A1LMNAKDM4EHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121054-A | DIVIDING FLUIDS AND PRECIPITATES; POSITIONING MULTICOMPARTMENT VESSELS ON SUPPORTS, SPINNING A CENTRIFUGE, ALLOWING PRECIPITATES TO SEDIMENT INTO VESSELS, EXCESS FLUIDS WILL BE EJECTED FROM THE TOP OF THE VESSEL | TREGA BIOSCIENCES, INC. (US) | 2000-09-19 | — | — | US | disclosed |