Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.56 |
| ▸ | MTOR | P42345 | 10/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.56 |
| ▸ | ATR | Q13535 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.40 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212640 | 0.93 | PIK3CA (0.51) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL3588038 | 0.86 | PIK3CA (0.76) | PIK3CAMTORPIK3CDATR | |
| SCHEMBL8098212 | 0.86 | PIK3CA (0.53) | PIK3CAMTORPIK3CD | |
| SCHEMBL8206186 | 0.83 | RAB9A (0.45) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8205208 | 0.83 | PIK3CA (0.42) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL3606853 | 0.83 | PIK3CA (0.77) | PIK3CAMTORPIK3CDATR | |
| SCHEMBL8099387 | 0.83 | PIK3CA (0.52) | PIK3CAMTORPIK3CD | |
| SCHEMBL8214242 | 0.82 | CYP3A4 (0.44) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL8219567 | 0.82 | PIK3CA (0.42) | PIK3CAMTORPIK3CDCA12CA1 | |
| SCHEMBL3592636 | 0.81 | PIK3CA (0.74) | PIK3CAMTORPIK3CDATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |