SCHEMBL8213486

SCHEMBL8213486

C=COC(=O)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.53
EPHX1 P07099 2/20 0.53
ALDH1A1 P00352 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
LMNA P02545 1/20 0.46
THRB P10828 1/20 0.46
HTT P42858 1/20 0.46
KMT2A Q03164 3/20 0.44
MEN1 O00255 2/20 0.44
MAPK1 P28482 1/20 0.44
MAPT P10636 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11247595 0.77 EPHX2 (0.58) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
SCHEMBL14341840 0.76 EPHX2 (0.61) EPHX2EPHX1ALDH1A1SMN1; SMN2KMT2A
SCHEMBL28251636 0.75 EPHX2 (0.59) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
SCHEMBL1070205 0.75 EPHX2 (0.59) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
SCHEMBL14644904 0.73 EPHX2 (0.57) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
Acrylic Acid SCHEMBL31456574 0.73 LMNA (0.49) EPHX2ALDH1A1SMN1; SMN2LMNATHRB
SCHEMBL28690139 0.72 ALDH1A1 (0.50) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
SCHEMBL771405 0.71 EPHX2 (0.67) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA
SCHEMBL5374123 0.71 MAPT (0.44) ALDH1A1LMNAKMT2AMEN1MAPT
SCHEMBL18884208 0.71 EPHX2 (0.73) EPHX2EPHX1ALDH1A1SMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6166236-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 2000-12-26 US claimed
EP-0396364-B1 Copolymers of vinyl carbonate and vinyl carbamate as contact lens material BAUSCH & LOMB (US) 1997-06-11 EP claimed
US-5610252-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1997-03-11 US claimed
EP-0396364-A2 Novel vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1990-11-07 EP claimed
US-6166236-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 2000-12-26 US disclosed
EP-0757033-B1 Vinyl carbonate and vinyl carbamate monomers for a contact lens material BAUSCH & LOMB (US) 1999-03-03 EP disclosed
EP-0559820-B1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB (US) 1998-02-18 EP disclosed
EP-0396364-B1 Copolymers of vinyl carbonate and vinyl carbamate as contact lens material BAUSCH & LOMB (US) 1997-06-11 EP disclosed
US-5610252-A Vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1997-03-11 US disclosed
EP-0560916-B1 Method of molding of silicon-containing contact lenses BAUSCH & LOMB (US) 1997-02-05 EP disclosed
EP-0757033-A2 Vinyl carbonate and vinyl carbamate monomers for a contact lens material BAUSCH & LOMB INCORPORATED (US) 1997-02-05 EP disclosed
EP-0559809-B1 SURFACE MODIFICATION OF POLYMER OBJECTS BAUSCH & LOMB (US) 1996-11-06 EP disclosed
US-5177165-A Contact lenses BAUSCH & LOMB INCORPORATED (US) 1993-01-05 US disclosed
US-5158717-A Contact lenses from copolymerizing silicone and hydrophilic monomers in mold produced from an acrylonitrile copolymer resin; melt processability, wettability BAUSCH & LOMB INCORPORATED (US) 1992-10-27 US disclosed
US-5135297-A Immersing a contact lens in an aqueous dispersion of a polymerizable surfactant macromer, a crosslinker and a free radical catalyst and irradiating with UV light; wetting agents BAUSCH & LOMB INCORPORATED (US) 1992-08-04 US disclosed
WO-1992009639-A2 SURFACE-ACTIVE MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO disclosed
WO-1992009650-A1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO disclosed
WO-1992009644-A1 SURFACE MODIFICATION OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO disclosed
US-5070215-A Gas permeable contact lenses BAUSCH & LOMB INCORPORATED (US) 1991-12-03 US disclosed
EP-0396364-A2 Novel vinyl carbonate and vinyl carbamate contact lens material monomers BAUSCH & LOMB INCORPORATED (US) 1990-11-07 EP disclosed