Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.78 |
| ▸ | CA1 | P00915 | 3/20 | 0.78 |
| ▸ | CA2 | P00918 | 3/20 | 0.78 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.78 |
| ▸ | PARP1 | P09874 | 1/20 | 0.78 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.78 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.61 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.57 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.57 |
| ▸ | VNN1 | O95497 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.53 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.53 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.53 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL201761 | 0.88 | PARP10 (1.00) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL28127922 | 0.88 | PARP10 (0.59) | PARP10CA1CA2PARP4PARP1 | |
| Hydrochloric Acid SCHEMBL4376056 | 0.86 | PARP10 (0.95) | PARP10CA1CA2PARP4PARP1 | |
| Hydrochloric Acid SCHEMBL408766 | 0.86 | PARP10 (0.95) | PARP10CA1CA2PARP4PARP1 | |
| Ethylene Glycol SCHEMBL1232077 | 0.85 | PARP10 (0.84) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL28232519 | 0.85 | RAB9A (0.63) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL12339549 | 0.84 | PARP10 (0.83) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL7134591 | 0.84 | PLA2G10 (0.83) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL28139163 | 0.84 | PARP1 (0.61) | PARP10CA1CA2PARP4PARP1 | |
| SCHEMBL11464459 | 0.83 | CA1 (0.77) | CA1CA2SAE1UBA2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140288127-A1 | Novel Alkene Oxindole Derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2014-09-25 | — | — | US | disclosed |
| US-8778973-B2 | Alkene oxindole derivatives | HOFFMANN-LAROCHE INC. (US) | 2014-07-15 | — | — | US | disclosed |
| US-20130131114-A1 | NOVEL ALKENE OXINDOLE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2013-05-23 | — | — | US | disclosed |
| EP-2480530-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. Hoffmann-La Roche AG (CH) | 2012-08-01 | — | — | EP | disclosed |
| WO-2011033099-A1 | ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288127-A1 | Novel Alkene Oxindole Derivatives | PRKAB1, PRKAR2A, PRKAB2 | PARP10 780/4885CA1 4752/4885CA2 3443/4885 |
| US-20130131114-A1 | NOVEL ALKENE OXINDOLE DERIVATIVES | PRKAB1, PRKAR2A, PRKAB2 | PARP10 780/4885CA1 4752/4885CA2 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.