Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.53 |
| ▸ | MTOR | P42345 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215047 | 0.91 | PIK3CA (0.55) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8216901 | 0.90 | PIK3CA (0.53) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8215041 | 0.87 | PIK3CA (0.66) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8205071 | 0.84 | PIK3CA (0.54) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8218782 | 0.84 | PIK3CA (0.54) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8218786 | 0.82 | PIK3CA (0.53) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8216854 | 0.82 | PIK3CA (0.52) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL3608637 | 0.82 | MTOR (0.81) | PIK3CAMTORPIK3CD | |
| SCHEMBL8213831 | 0.81 | PIK3CA (0.57) | PIK3CAMTORCA2MEN1KMT2A | |
| SCHEMBL8214218 | 0.81 | PIK3CA (0.66) | PIK3CAMTORPIK3CDKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |