Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11925701 | 0.87 | PIK3CA (0.41) | KDRPIK3CAMTORPIK3CGPTK2 | |
| SCHEMBL11925409 | 0.87 | GHSR (0.45) | KDRKITNAMPTPIK3CAMTOR | |
| SCHEMBL11926845 | 0.85 | F7 (0.38) | KDRPIK3CAMTORPIK3CGPTK2 | |
| SCHEMBL8212643 | 0.85 | ALDH1A1 (0.42) | KDRLMNANAMPTMCL1PIK3CA | |
| SCHEMBL8204518 | 0.85 | PIK3CA (0.46) | NAMPTPIK3CAMTORPIK3CG | |
| SCHEMBL8204574 | 0.83 | KIF11 (0.43) | LMNAMTORPTK2 | |
| SCHEMBL8211613 | 0.83 | KDR (0.43) | KDRLMNAKITPDGFRANAMPT | |
| SCHEMBL11925483 | 0.82 | KDR (0.43) | KDRLMNAKITPDGFRANAMPT | |
| SCHEMBL8213351 | 0.81 | TSHR (0.46) | KDRKITNAMPTPIK3CAMTOR | |
| SCHEMBL8221056 | 0.81 | PIK3CA (0.39) | KDRNAMPTPIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |