Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 6/20 | 0.35 |
| ▸ | ATRIP | Q8WXE1 | 6/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077731 | 0.87 | PIK3CA (0.52) | PIK3CAMTORRPTORMLST8PIK3CD | |
| SCHEMBL3088132 | 0.84 | PIK3CA (0.50) | PIK3CAMTORRPTORMLST8PIK3CD | |
| SCHEMBL8213979 | 0.80 | PIK3CA (0.55) | PIK3CAMTORRPTORMLST8PIK3CD | |
| SCHEMBL8097550 | 0.75 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4257169 | 0.71 | PIK3CA (0.55) | PIK3CAMTORRPTORMLST8PIK3CD | |
| SCHEMBL8092747 | 0.69 | PIK3CA (0.51) | PIK3CAMTORPIK3CDATRATRIP | |
| SCHEMBL9978862 | 0.68 | ATR (0.42) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL9979049 | 0.68 | ATR (0.42) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL9979071 | 0.68 | ATR (0.42) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL9979416 | 0.68 | ATR (0.42) | PIK3CAMTORPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |