SCHEMBL8214347

SCHEMBL8214347

C=Cc1ccc(CCCCCC[Si](OC)(OC)OC)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 6/20 0.36
THRA P10827 5/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
ALDH1A1 P00352 3/20 0.35
ALOX15 P16050 2/20 0.34
CALM1 P0DP23 1/20 0.34
IGF1R P08069 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
TRPA1 O75762 1/20 0.33
TP53 P04637 2/20 0.33
CYP3A4 P08684 2/20 0.33
TSHR P16473 1/20 0.33
ALOX12 P18054 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
ESR1 P03372 1/20 0.33
SHBG P04278 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28903598 1.00 THRB (0.36) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL11706646 0.98 ALDH1A1 (0.37) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL1664552 0.93 ALDH1A1 (0.38) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL12638196 0.87 ALDH1A1 (0.35) THRBTHRAALDH1A1CALM1TRPA1
SCHEMBL424493 0.86 ALDH1A1 (0.41) THRBMEN1KMT2AALDH1A1ALOX15
SCHEMBL25242964 0.84 CALM1 (0.44) ALDH1A1ALOX15CALM1IGF1RTDP1
SCHEMBL8760330 0.81 ALDH1A1 (0.39) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL594419 0.80 ALDH1A1 (0.55) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL6278400 0.80 ALDH1A1 (0.55) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL3797757 0.80 ALDH1A1 (0.55) THRBTHRAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1025145-A1 MEANS AND METHODS FOR ENHANCING INTERFACIAL ADHESION BETWEEN A METAL SURFACE AND A NON-METALLIC MEDIUM AND PRODUCTS OBTAINED THEREBY N.V. BEKAERT S.A. (BE) 2000-08-09 EP disclosed
WO-1999020682-A1 MEANS AND METHODS FOR ENHANCING INTERFACIAL ADHESION BETWEEN A METAL SURFACE AND A NON-METALLIC MEDIUM AND PRODUCTS OBTAINED THEREBY N.V. BEKAERT S.A. (BE) 1999-04-29 WO disclosed
US-4020043-A FLUORO-ALIPHATIC-SULFONYL-SUBSTITUTED ETHYLENE COMPOUND MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1977-04-26 US disclosed