Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | ACE | P12821 | 2/20 | 0.41 |
| ▸ | KDM6B | O15054 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16706125 | 0.87 | KDM6B (0.55) | FOLH1HSP90AA1HSP90AB1CA2MME | |
| SCHEMBL22956979 | 0.87 | KDM6B (0.55) | FOLH1HSP90AA1HSP90AB1CA2MME | |
| SCHEMBL31248186 | 0.87 | KDM6B (0.55) | FOLH1HSP90AA1HSP90AB1CA2MME | |
| SCHEMBL7900190 | 0.81 | FOLH1 (0.41) | FOLH1CA2MMEACEACE2 | |
| SCHEMBL10657017 | 0.81 | ACE (0.57) | ACEITGB1ITGA4 | |
| SCHEMBL10657027 | 0.81 | ACE (0.57) | ACEITGB1ITGA4 | |
| SCHEMBL4963554 | 0.81 | PPARG (0.46) | HSP90AA1HSP90AB1CA2KDM6BALOX15 | |
| SCHEMBL30891619 | 0.80 | KDM6B (0.45) | HSP90AA1HSP90AB1MMEKDM6BALOX15 | |
| SCHEMBL9845237 | 0.80 | KDM6B (0.45) | HSP90AA1HSP90AB1KDM6BALOX15HSD17B10 | |
| SCHEMBL953389 | 0.79 | FOLH1 (0.56) | FOLH1CA2MMEACECA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140100-A | CONJUGATE POLYPEPTIDE WHICH IS TISSUE PREFERENTIAL; ANTICARCINOGENIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-10-31 | — | — | US | disclosed |