Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 4/20 | 0.41 |
| ▸ | ACE | P12821 | 5/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 5/20 | 0.36 |
| ▸ | CPA1 | P15085 | 3/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7898816 | 0.87 | HDAC3 (0.41) | FOLH1ACEITGB3ITGA2BCA2 | |
| SCHEMBL7900674 | 0.85 | ACE (0.46) | ACEITGB3ITGA2BMMECTSS | |
| SCHEMBL9287295 | 0.83 | ACE (0.38) | FOLH1ACEITGB3ITGA2BCA2 | |
| SCHEMBL8215159 | 0.81 | FOLH1 (0.43) | FOLH1ACECA2MMEACE2 | |
| SCHEMBL10657027 | 0.80 | ACE (0.57) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL10657017 | 0.80 | ACE (0.57) | ACEITGB3ITGA2BPTPN1CTSS | |
| SCHEMBL7261799 | 0.80 | MMP1 (0.38) | CTSSCTSKCTSBHDAC3HDAC4 | |
| SCHEMBL7257429 | 0.79 | CTSL (0.43) | ACEPTPN1CTSSCTSKCTSB | |
| SCHEMBL8214039 | 0.77 | ACE (0.41) | ACEMMECPA1ACE2CTSS | |
| SCHEMBL9101075 | 0.76 | FOLH1 (0.51) | FOLH1ACECA2NAALAD2MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6319702-B1 | NUCLEOTIDE SEQUENCS CODING AN ENZYMATIC POLYPEPTIDE AND CELL TARGETING COMPOUND; FOR USE IN TREATMENT OF CANCER | GLAXO WELLCOME, INC. | 2001-11-20 | — | — | US | disclosed |