Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215437 | 0.84 | PIK3CA (0.46) | NPC1RAB9AFLT3SMN1; SMN2ADORA3 | |
| SCHEMBL8206190 | 0.81 | PIK3CD (0.43) | PIK3CAMTORMEN1KMT2APIK3CD | |
| SCHEMBL8084637 | 0.81 | CA12 (0.45) | PIK3CAMTORMEN1KMT2APIK3CD | |
| SCHEMBL8098332 | 0.81 | PIK3CA (0.48) | RAB9APIK3CAMTORMEN1KMT2A | |
| SCHEMBL11925577 | 0.80 | LMNA (0.45) | NPC1RAB9AFLT3SMN1; SMN2ADORA3 | |
| SCHEMBL8205071 | 0.80 | PIK3CA (0.54) | LMNAPIK3CAMTORMEN1KMT2A | |
| SCHEMBL8091882 | 0.79 | PIK3CA (0.45) | FLT3SMN1; SMN2AURKBLIMK1PIK3CA | |
| SCHEMBL8217167 | 0.79 | PIK3CA (0.40) | PIK3CAMTORMEN1KMT2APIK3CD | |
| SCHEMBL8217546 | 0.79 | L3MBTL1 (0.55) | NPC1RAB9ASMN1; SMN2PIK3CAMEN1 | |
| SCHEMBL13948517 | 0.79 | PIK3CA (0.67) | PIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |