Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.53 |
| ▸ | MEN1 | O00255 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.53 |
| ▸ | RELA | Q04206 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8218157 | 0.99 | KMT2A (0.52) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8221080 | 0.88 | MAPT (0.54) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8218987 | 0.87 | MAPT (0.53) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8201498 | 0.85 | MAPT (0.48) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8221068 | 0.84 | MAPT (0.47) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8218244 | 0.84 | MAPT (0.45) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| Hydrochloric Acid SCHEMBL8222018 | 0.83 | MAPT (0.44) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL8209221 | 0.83 | MAOB (0.52) | MAPTSMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL8201457 | 0.83 | DRD2 (0.45) | MAPTSMN1; SMN2NPC1RAB9ANFKB1 | |
| SCHEMBL8221093 | 0.83 | MAPT (0.44) | KMT2AMEN1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | claimed |
| WO-2000008023-A1 | CONDENSED TRICYCLIC PIPERIDINES HAVING ANTI-CONVULSANT ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-17 | — | — | WO | disclosed |