SCHEMBL8215591

SCHEMBL8215591

CCCCCCC1=C([Si](C)(C)NC2CCCCC2)CC=C1

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 9/20 0.37
EPHX2 P34913 3/20 0.37
SIGMAR1 Q99720 2/20 0.33
NPC1 O15118 2/20 0.33
RAB9A P51151 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
ALDH1A1 P00352 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
CNR1 P21554 3/20 0.32
CNR2 P34972 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8214706 0.83 CNR2 (0.36) EPHX1EPHX2SMN1; SMN2PDE4APDE4B
SCHEMBL8215609 0.83 CNR2 (0.36) EPHX1EPHX2SMN1; SMN2PDE4APDE4B
SCHEMBL8215565 0.80 CNR2 (0.37) EPHX1EPHX2CNR1CNR2
SCHEMBL8215519 0.78 KCNH2 (0.31)
SCHEMBL8219925 0.78 KCNH2 (0.31)
SCHEMBL8220116 0.76
SCHEMBL8220729 0.76
SCHEMBL8214709 0.76
SCHEMBL8216488 0.74
SCHEMBL8218241 0.73 LMNA (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136995-A Process for producing aminosilane compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-24 US disclosed