SCHEMBL8215609

SCHEMBL8215609

CCCCCCC1=C([Si](C)(NC2CCCCC2)c2ccccc2)CC=C1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 7/20 0.36
CNR1 P21554 4/20 0.36
EPHX1 P07099 1/20 0.35
EPHX2 P34913 1/20 0.35
FLT3 P36888 1/20 0.34
TYRO3 Q06418 1/20 0.34
MERTK Q12866 1/20 0.34
GAS6 Q14393 1/20 0.34
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ICMT O60725 1/20 0.33
ALB P02768 1/20 0.33
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
FAAH O00519 2/20 0.32
CTSS P25774 1/20 0.31
CTSK P43235 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8214706 1.00 CNR2 (0.36) CNR2CNR1EPHX1EPHX2FLT3
SCHEMBL8215565 0.87 CNR2 (0.37) CNR2CNR1EPHX1EPHX2FLT3
SCHEMBL8215591 0.83 EPHX1 (0.37) CNR2CNR1EPHX1EPHX2SMN1; SMN2
SCHEMBL8215587 0.82 NPC1 (0.33) SMN1; SMN2TP53
SCHEMBL8215470 0.82 NPC1 (0.33) SMN1; SMN2TP53
SCHEMBL8219911 0.81 LMNA (0.33) EPHX2KDM4ELMNASMN1; SMN2MAPT
SCHEMBL8215548 0.80 GPR84 (0.33)
SCHEMBL8215488 0.80 NPC1 (0.32) SMN1; SMN2TP53
SCHEMBL8218131 0.80 NPC1 (0.32) SMN1; SMN2TP53
SCHEMBL8216335 0.79 KCNH3 (0.35) LMNASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136995-A Process for producing aminosilane compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-10-24 US disclosed