Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 8/20 | 0.69 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8225905 | 0.92 | CACNA1H (0.78) | CACNA1HTRPV1 | |
| SCHEMBL8224175 | 0.89 | CACNA1H (0.86) | CACNA1HTRPV1CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL8226349 | 0.88 | CACNA1H (0.84) | CACNA1HTRPV1NPC1 | |
| SCHEMBL8228087 | 0.87 | CACNA1H (0.58) | CACNA1HTRPV1SMN1; SMN2 | |
| SCHEMBL13595875 | 0.86 | CACNA1H (0.83) | CACNA1HTRPV1 | |
| SCHEMBL8226558 | 0.86 | CACNA1H (0.72) | CACNA1HTRPV1NPC1TP53RAB9A | |
| SCHEMBL8229860 | 0.85 | CACNA1H (0.56) | CACNA1HTRPV1CYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL8224751 | 0.84 | CACNA1H (0.84) | CACNA1HTRPV1ALDH1A1CYP2D6NPC1 | |
| SCHEMBL13595868 | 0.83 | CACNA1H (0.78) | CACNA1HTSHRALDH1A1NPC1RAB9A | |
| SCHEMBL8227800 | 0.83 | CACNA1H (0.64) | CACNA1HTRPV1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033460-A2 | TREATING PAIN, DIABETES, AND LIPID METABOLISM DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |