Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.42 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13595989 | 0.92 | CACNA1H (0.67) | CACNA1HGAAKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL8229860 | 0.88 | CACNA1H (0.56) | CACNA1HKMT2ALMNATRPV1 | |
| SCHEMBL8217909 | 0.87 | CACNA1H (0.69) | CACNA1HSMN1; SMN2TRPV1 | |
| SCHEMBL8224721 | 0.83 | CACNA1H (0.67) | CACNA1HKMT2ASMN1; SMN2 | |
| SCHEMBL13595941 | 0.82 | CACNA1H (0.71) | CACNA1HGAAKMT2AP2RX7FAAH | |
| SCHEMBL8226558 | 0.82 | CACNA1H (0.72) | CACNA1HSMN1; SMN2LMNATRPV1 | |
| SCHEMBL8225905 | 0.82 | CACNA1H (0.78) | CACNA1HKMT2ATRPV1 | |
| SCHEMBL8224175 | 0.81 | CACNA1H (0.86) | CACNA1HSMN1; SMN2TRPV1 | |
| SCHEMBL13595986 | 0.81 | CACNA1H (0.73) | CACNA1HTRPV1 | |
| SCHEMBL8226349 | 0.80 | CACNA1H (0.84) | CACNA1HTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033460-A2 | TREATING PAIN, DIABETES, AND LIPID METABOLISM DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |