Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 3/20 | 0.54 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.54 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.41 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459961 | 0.84 | GNAI3 (0.58) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL14275539 | 0.84 | GNAI3 (0.58) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL1562717 | 0.84 | GNAI3 (0.72) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL3007222 | 0.77 | L3MBTL3 (0.41) | GNAI3GNAO1GNAI1CHRM1CACNA1B | |
| SCHEMBL14614943 | 0.76 | MEN1 (0.59) | CHRM1MEN1KMT2ACHRM2CHRM3 | |
| SCHEMBL12945382 | 0.75 | CHRNB2 (0.50) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL13059409 | 0.75 | CHRNB2 (0.50) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL8223865 | 0.75 | CHRM1 (0.42) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 | |
| SCHEMBL13459406 | 0.74 | GNAI3 (0.69) | GNAI3GNAO1GNAI1CACNA1BMEN1 | |
| SCHEMBL14275799 | 0.74 | MEN1 (0.55) | GNAI3GNAO1GNAI1CHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007142583-A1 | MUSCARINIC RECEPTOR AGONISTS THAT ARE EFFECTIVE IN THE TREATMENT OF PAIN, ALZHEIMER'S DISEASE AND SCHIZOPHRENIA. | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |