Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092873 | 0.70 | KDM4E (0.31) | KDM4E | |
| SCHEMBL14654286 | 0.70 | L3MBTL1 (0.52) | LMNASMN1; SMN2TSHRKDM4EALDH1A1 | |
| SCHEMBL21469842 | 0.66 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2TSHRALDH1A1FAAH | |
| Sulfuric Acid SCHEMBL31086526 | 0.65 | LMNA (0.50) | LMNASMN1; SMN2TSHRKDM4EMAPK1 | |
| Sulfuric Acid SCHEMBL10413938 | 0.65 | LMNA (0.50) | LMNASMN1; SMN2TSHRKDM4EMAPK1 | |
| SCHEMBL1755619 | 0.65 | POLB (0.33) | — | |
| SCHEMBL14943820 | 0.64 | LMNA (0.36) | LMNASMN1; SMN2TSHRALDH1A1FAAH | |
| SCHEMBL16121719 | 0.62 | LMNA (0.39) | LMNASMN1; SMN2TSHRALDH1A1FAAH | |
| SCHEMBL1175599 | 0.61 | — | — | |
| SCHEMBL21266696 | 0.61 | HTT (0.43) | LMNASMN1; SMN2TSHRALDH1A1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |